Amazon Athena is a serverless, interactive analytics service designed to work with open-source frameworks and support open-table and file formats. It offers a flexible, straightforward method to analyze massive datasets in their existing locations. Using SQL or Python, data can be queried directly from an Amazon S3 data lake. Athena is powered by open-source engines like Trino and Presto, as well as Apache Spark, and requires no setup or configuration, allowing for immediate use.